期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 5, 页码 464-471出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800252
关键词
adhesives; biomimetic; complex coacervation; phase behavior; polyelectrolytes
资金
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [0906014] Funding Source: National Science Foundation
- NIBIB NIH HHS [R01 EB006463, R01 EB006463-01A1] Funding Source: Medline
Polyacrylate glue protein analogs of the glue secreted by Phragmatopoma californica, a marine polycheate, were synthesized with phosphate, primary amine, and catechol sidechains with molar ratios similar to the natural glue proteins. Aqueous mixtures of the mimetic polyelectrolytes condensed into liquid complex coacervates around neutral pH. Wet cortical bone specimens bonded with the coacervates, oxidatively crosslinked through catechol sidechains, had bond strengths nearly 40% of the strength of a commercial cyanoacrylate. The unique material properties of complex coacervates may be ideal for development of clinically useful adhesives and other biomaterials.
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