期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 7, 页码 671-676出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800317
关键词
biological applications of polymers; drug delivery systems; hydrogels; implants; proteins
资金
- Ministry of Education, Science and Technology [F104AA010004-06A0101-00410, 2008-00889]
- Seoul R BD program [CR070027]
- National Research Foundation of Korea [2005-2000115] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Injectable delivery systems for therapeutic proteins (e.g., hydrogels and microspheres) have attracted wide attention. Hydrogels, however, may release their hydrophilic contents too rapidly in a large initial burst, and phagocytes may clear microspheres within a relatively short time period after administration. We hypothesized that micro sphere/hydrogel combination systems could achieve a controlled and sustained release of proteins as an injectable delivery system. To test this hypothesis, we prepared PLGA microspheres containing a model protein and mixed these with alginate gels. The mixing ratio of the components was the primary controlling parameter of the protein release. This approach could be useful for development of injectable and localized drug delivery systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据