期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 1, 页码 102-111出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800189
关键词
antibacterial activity; chitosan; electrospinning; nanotechnology; poly[(L-lactide)-co-(D,L-lactide)]; wound healing
资金
- Bulgarian National Science Fund [NT-4-01/04]
Continuous defect-free nanofibers containing chitosan (Ch) or quaternized chitosan (QCh) were successfully prepared by one-step electrospinning of Ch or QCh solutions mixed with poly[(L-lactide)-co-(D,L-lactide)] in common solvent. XPS revealed the surface chemical composition of the bicomponent electrospun mats. Crosslinked Ch- and QCh-containing nanofibers exhibited higher kill rates against bacteria S. aureus and E. coli than the corresponding solvent-cast films. SEM observations showed that hybrid mats were very effective in suppressing the adhesion of pathogenic bacteria S. aureus. The hybrid nanofibers are promising for wound-healing applications. containing chitosan step electrospinning
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