期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 1, 页码 63-70出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800150
关键词
adsorption; biocompatibility; biological application of polymers; biomaterials; proteins
资金
- Japan Society for the Promotion of Science [19350055]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [20750175]
- Grants-in-Aid for Scientific Research [19350055, 20750175] Funding Source: KAKEN
The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property.
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