期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 2, 页码 140-156出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800284
关键词
drug delivery; extracellular matrix; heparin; hyaluronic acid; hybrid hydrogels; microgels; networks; polysaccharide particles; tissue engineering
资金
- National Institutes of Health [R01 DC008965, 1 R01 EB00317201]
- National Science Foundation [DMR-0643226, DBE-0221651]
- Arnold and Mabel Beckman Foundation
Artificial ECMs that not only closely mimic the hybrid nature of the natural ECM but also provide tunable material properties and enhanced biological functions are attractive candidates for tissue engineering applications. This review summarizes recent advances in developing multicomponent hybrid hydrogels by integrating modular and heterogeneous building blocks into well-defined, multifunctional hydrogel composites. The individual building blocks can be chemically, morphologically, and functionally diverse, and the hybridization can occur at molecular level or microscopic scale. The modular nature of the designs, combined with the potential synergistic effects of the hybrid systems, has resulted in novel hydrogel matrices with robust structure and defined functions.
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