期刊
MACROMOLECULAR BIOSCIENCE
卷 9, 期 9, 页码 857-863出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800371
关键词
BSA; ionic crosslinking; nanoparticles; protein carriers; quaternized cellulose; structure
资金
- National High Technology Research and Development Program of China [2004AA649250]
- National Natural Science Foundation of China [20204011, 20674057]
Quaternized cellulose (QC) nanciparticles were prepared in distilled water by ionic crosslinking of QC with sodium tripolyphosphate (TPP) for the first time. BSA as a model protein drug was used to investigate the loading and release features of the nanciparticles. The results indicated that QC nanoparticles had high loading efficiency and capacity for BSA. The in vitro BSA release of the QC nanoparticles displayed a burst effect in the first 2 h and then a slow continuous release. Nanoparticles with a higher DS of QC showed a decrease in particle size, an increase in zeta potential, a higher loading efficiency and a slower drug-release profile. These studies demonstrated that QC nanoparticles are potential protein carriers, and that their physicochernical properties and release profile could be easily adjusted.
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