Composite nano-titanium oxide-chitosan artificial skin exhibits strong wound-healing effect - An approach with anti-inflammatory and bactericidal kinetics

A composite nano-TiO2-chitosan with Collagen artificial skin (NTCAS) showed promising characteristics of moderate water absorptivity (110 wt.-%), fine thickness (0.34 mm), low density (0.33 mg . mm(-3)), moderate biodegradability (<3.0%), and favorable time-dependent biodegradability (0.0521 mg . mL(-1) . h(-1) on Day 0; 0.0006 mg . mL(-1) . h(-1) on Day 3 post covering). More importantly, it showed uniquely potent bactericidal (sterilization) property with relatively large values of pseudo first-order kinetic coefficients (0.1736-0.0360 min(-1)) for TiO2 contents ranging from 2.63 x 10(-5) to 2.11 x 10(-4)