期刊
MACROMOLECULAR BIOSCIENCE
卷 8, 期 11, 页码 1044-1052出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200800175
关键词
biodegradable; drug delivery systems; gels; graft copolymers; self-assembly
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
We showed previously that poly(L-lactide)-grafted dextran could form biodegradable nanogels in water. In this paper, various properties of Dex-g-PLLA nanogels were compared with Dex-Chol (dextran-cholesterol conjugate) nanogels to investigate the effects of hydrophobic units. Dex-g-PLLA nanogels exhibited significantly lower CAC and higher colloidal stability, indicating a strong tendency to form nanogels. We prepared lysozyme-loaded Dex-g-PLLA nanogels, and they exhibited a sustained release of lysozyme for 1 week without denaturation in PBS at 37 degrees C. The Dex-g-PLLA nanogels therefore have great potential as a delivery vehicle for therapeutic protein.
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