Biodegradable and biomimetic poly(ε-caprolactone)/poly(lactobionarnidoethyl methacrylate) biohybrids:: Synthesis, lactose-installed nanoparticles and recognition properties

Biodegradable and biomimetic SPICL-PLAMA biohybrids were synthesized via ATRP and characterized by FT-IR, H-1 NMR, GPC and DSC. Biohybrids with small PDI were obtained, and the block length of the PLAMA glycopolymer could be varied linearly by the varying the molar ratio of glycomonomer to macroinitiator. The outer PLAMA glycopolymer restrained the crystallization of inner PCL segments. The self-assembly properties of amphiphilic biohybrids were studied. Lactose-installed aggregates were fabricated in aqueous solution; they changed from spherical micelles to vesicles with increasing weight fraction of hydrophobic PCL. The SPCL-PLAMA biohybrids showed specific recognition for RCA(120) lectin.