期刊
MACROMOLECULAR BIOSCIENCE
卷 8, 期 3, 页码 247-259出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200700165
关键词
acryloylated polyaspartamide; drug delivery; polymeric; PEGylated nanoparticles; rivastigmine; UV irradiation; water/oil microemulsion
The preparation and characterization of surface-PE Gylated polymeric nanoparticles are described. These systems were obtained by UV irradiation of PHM and PHM-PEG(2000) as an inverse microemulsion, using an aqueous solution of the PHM/PHM-PEG(2000) copolymer mixture as the internal phase and triacetin saturated with water as the external phase, and characterized by dimensional analysis, zeta-potential measurements and XPS. in vitro biological tests demonstrated their cell compatibility and their ability to escape from phagocytosis. Rivastigmine was encapsulated into the nanoparticle structure and drug-release profiles from loaded samples were investigated in PBS at pH = 7.4 and human plasma.
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