期刊
MABS
卷 6, 期 3, 页码 773-781出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/mabs.28612
关键词
interleukin 6; IL-6; antibody; site 3; gp130; olokizumab; neutralization; structure
Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease. Here, we describe the discovery and characterization of olokizumab, a humanized antibody to IL-6. Data from structural biology, cell biology and primate pharmacology demonstrate the therapeutic potential of targeting IL-6 at Site 3, blocking the interaction with the signaling co-receptor gp130.
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