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Janice M. Reichert
MABS (2014)
Qualification of a homogeneous cell-based neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics
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Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies
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A strategy for risk mitigation of antibodies with fast clearance
Isidro Hoetzel et al.
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FcRn Affinity-Pharmacokinetic Relationship of Five Human IgG4 Antibodies Engineered for Improved In Vitro FcRn Binding Properties in Cynomolgus Monkeys
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JOURNAL OF IMMUNOLOGICAL METHODS (2011)
Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
Weirong Wang et al.
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Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies
Imre Kacskovics et al.
MABS (2011)
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Timothy T. Kuo et al.
MABS (2011)
Engineering the variable region of therapeutic IgG antibodies
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MABS (2011)
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Nigel M. Stapleton et al.
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Pharmacokinetics of Humanized Monoclonal Anti-Tumor Necrosis Factor-α Antibody and Its Neonatal Fc Receptor Variants in Mice and Cynomolgus Monkeys
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Cross-species Binding Analyses of Mouse and Human Neonatal Fc Receptor Show Dramatic Differences in Immunoglobulin G and Albumin Binding
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Importance of Neonatal FcR in Regulating the Serum Half-Life of Therapeutic Proteins Containing the Fc Domain of Human IgG1: A Comparative Study of the Affinity of Monoclonal Antibodies and Fc-Fusion Proteins to Human Neonatal FcR
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JOURNAL OF IMMUNOLOGY (2010)
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Tomoyuki Igawa et al.
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Enhanced antibody half-life improves in vivo activity
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Reduced elimination of IgG antibodies by engineering the variable region
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Anti-p40 Antibodies Ustekinumab and Briakinumab: Blockade of Interleukin-12 and Interleukin-23 in the Treatment of Psoriasis
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Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates
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JOURNAL OF IMMUNOLOGY (2009)
Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors
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Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation
Dingjiang Liu et al.
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Jan Van den Brulle et al.
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Molecular engineering and design of therapeutic antibodies
Leonard G. Presta
CURRENT OPINION IN IMMUNOLOGY (2008)
A strategy for bacterial production of a soluble functional human neonatal Fc receptor
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JOURNAL OF IMMUNOLOGICAL METHODS (2008)
The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies
Christine Rothe et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Monoclonal antibody clearance -: Impact of modulating the interaction of IgG with the neonatal Fc receptor
Amita Datta-Mannan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Humanized IgG(1) variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates
Amita Datta-Mannan et al.
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Derry C. Roopenian et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies
Carlos Vaccaro et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin
Jan Terje Andersen et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2006)
Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)
William F. Dall'Acqua et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Perspective - FcRn transports albumin: relevance to immunology and medicine
Clark L. Anderson et al.
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Development of new models for the analysis of Fc-FcRn interactions
BM Gurbaxani et al.
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Albumin turnover: FcRn-mediated recycling saves as much albumin from degradation as the liver produces
JH Kim et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
An engineered human IgG1 antibody with longer serum half-life
PR Hinton et al.
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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels
C Vaccaro et al.
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Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis
JC Zhou et al.
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S Ewert et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Increasing the affinity of a human IgG1, for the neonatal Fc receptor: Biological consequences
WF Dall'Acqua et al.
JOURNAL OF IMMUNOLOGY (2002)
Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies
RJ Ober et al.
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Crystal structure at 2.8 Å of an FcRn/heterodimeric Fc complex:: Mechanism of pH-dependent binding
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J Schuurman et al.
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AP West et al.
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JOURNAL OF MOLECULAR BIOLOGY (2000)