期刊
MABS
卷 6, 期 1, 页码 54-72出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/mabs.27029
关键词
IgE; antibodies; IgE immunotherapy; cancer immunotherapy; antibody effector functions; AllergoOncology
资金
- Cancer Research UK [C30122/A11527]
- KCL Experimental Cancer Medicine Centre - Cancer Research UK
- National Institute for Health Research
- Welsh Assembly Government
- HSC R&D Office for Northern Ireland
- Chief Scientist Office, Scotland
- CR UK/EPSRC/MRC/NIHR KCL/UCL Comprehensive Cancer Imaging Centre [C1519/A10331]
- National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- MRC [G1100090] Funding Source: UKRI
- Academy of Medical Sciences (AMS) [AMS-SGCL10-Josephs] Funding Source: researchfish
- Medical Research Council [G1000758B, G1100090] Funding Source: researchfish
- National Institute for Health Research [CL-2012-17-005] Funding Source: researchfish
The importance of antibodies in activating immune responses against tumors is now better appreciated with the emergence of checkpoint blockade antibodies and with engineered antibody Fc domains featuring enhanced capacity to focus potent effector cells against cancer cells. Antibodies designed with Fc regions of the IgE class can confer natural, potent, long-lived immune surveillance in tissues through tenacious engagement of high-affinity cognate Fc receptors on distinct, often tumor-resident immune effector cells, and through ability to activate these cells under tumor-induced Th2-biased conditions. Here, we review the properties that make IgE a contributor to the allergic response and a critical player in the protection against parasites, which also support IgE as a novel anti-cancer modality. We discuss IgE-based active and passive immunotherapeutic approaches in disparate in vitro and in vivo model systems, collectively suggesting the potential of IgE immunotherapies in oncology. Translation toward clinical application is now in progress.
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