期刊
MABS
卷 3, 期 4, 页码 352-361出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/mabs.3.4.16092
关键词
IgA; SIgA; dIgA; CD89; FcaRI; therapy; pro-inflammatory; mucosal defence; tumor; ITAM
资金
- Netherlands Organization for Scientific Research [VIDI 016.086.320]
Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non- and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.
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