IAPs: a central element in the NF-κB activating signaling pathway

IAPs: a central element in the NF-kappa B activating signaling pathway The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-kappa B activation. In this review, we will discuss the central role of clAP1, clAP2 and XIAP in the regulation of NE-kappa B activating signaling pathways. lozenge