Resveratrol nanodispersion with high stability and dissolution rate

Resveratrol is a highly polyphenolic substance which possesses extensive physiological activities. However, its application is limited by light instability and poor aqueous solubility. In this paper, resveratrol nanodispersion with high light stability and water dissolution rate was prepared by a combination of antisolvent precipitation in the presence of nontoxic polymer and spray-drying. The active ingredients of the unprocessed raw resveratrol decreased 80 wt% when exposed to sun light directly, while that of the resveratrol nanodispersion only reduced 14 wt% at the same condition. The resveratrol nanodispersion dissolved completely in less than 45 min, while raw resveratrol didn't dissolve completely after 120 min. Meanwhile, resveratrol nanodispersion exhibited better antioxidant activity compared to that of raw resveratrol when added in artificial intestinal juice. This study is helpful to promote the application of resveratrol and provides a routine for enhancing stability and water solubility of photosensitive lipophilic materials. (C) 2012 Elsevier Ltd. All rights reserved.