期刊
LUPUS
卷 20, 期 2, 页码 120-124出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203310389100
关键词
lupus nephritis; IL-17; IL-23; double negative T cells; tissue damage
类别
资金
- National Institutes of Health [R01 AI043043, R01 AI042269, RO1 AI049954, T32 AI074549]
Significant evidence implicates interleukin-17 (IL-17) in the pathogenesis of systemic lupus erythematosus (SLE), particularly in the development of tissue damage. IL-17 production and IL-17-producing CD4+ and CD3+ CD4-CD8- cells are increased in patients with SLE. IL-17-producing cells are present in the inflamed kidney tissues from patients with lupus nephritis. In lupus-prone mice, IL-17 production appears to be involved in the expression of disease pathology and pharmacologic or genetic manipulation of its production results in suppression of the disease. It becomes obvious that the use of biologics including humanized anti-IL-17 antibodies or decoy IL-17 receptors deserve clinical consideration. Similarly, the development of drugs that suppress the production of IL-17 is in order. Lupus (2011) 20, 120-124.
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