期刊
LUPUS
卷 18, 期 13, 页码 1181-1185出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203309346653
关键词
autoantibodies; autoimmunity; cross-reactivity; Epstein-Barr virus; infections; molecular mimicry; systemic lupus erythematosus
类别
Systemic lupus erythematosus is a multi-systemic autoimmune disease distinguished by the presence of various autoantibodies. Like most autoimmune diseases, systemic lupus erythematosus is believed to be induced by a combination of genetic, immunologic, and environmental factors, mainly infectious agents. Molecular mimicry between an infectious antigen and self-components is implicated as a pivotal mechanism by which autoimmune diseases such as systemic lupus erythematosus are triggered. Here we review the current evidence of molecular mimicry between different infectious agents and systemic lupus erythematosus. Lupus (2009) 18, 1181-1185.
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