期刊
LUPUS
卷 17, 期 6, 页码 528-532出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203308089402
关键词
B cells; mouse model; auto antibodies; oestrogen; prolactin
类别
The prevalence of systemic lupus erythematosus (SLE) is far higher in females than in males and numerous investigations to understand this gender bias have been performed, which propose as casual actors genetic predispositions and sex hormones effects. We will describe in this review how the sex hormones estrogen and prolactin influence B cell maturation and selection, permitting B cells to mature to immunocompetence in a mouse model of lupus. Finally, we will discuss the relevance and implications of these results for human disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据