期刊
LUPUS
卷 17, 期 1, 页码 34-39出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203307085248
关键词
CD4(+)CD25(+) T cells; inflammation; primary Sjogren's syndrome
类别
资金
- National Science Council, Taiwan, R.O.C [NSC93-2314-B006-051]
CD4(+)CD25(+bright) T cells played a crucial role in the suppression of immune response. Recently, decreased levels of CD4(+)CD25(+bright) T cells in the peripheral blood of patients with systemic lupus erythematosus were reported, suggesting the potential role of CD4(+)CD25(+bright) T cells in human autoimmune diseases. Primary Sjogren's syndrome (pSS) is another common human systemic autoimmune disease. The present study aimed to investigate the levels of CD4(+)CD25(+bright) T cells in pSS and to correlate their levels with some biomarkers of inflammation and immune activation. Thirty-three patients with pSS and 35 age- and sex-matched normal individuals were enrolled in the study. The flowcytometric method was applied in the measurement of CD4(+)CD25(+bright) T cells. The results showed that patients with pSS had statistically lower levels of CD4(+)CD25(+bright) T cells than normal controls, expressed either as absolute cell numbers (mean +/- SD: 47.07 +/- 25.53 cells/mm(3) versus 79.55 +/- 34.56 cells/mm(3), P < 0.001) or as percentages of peripheral blood mononuclear cells (mean +/- SD: 2.79 +/- 1.06% versus 3.84 +/- 1.42%, P < 0.001) or as percentages of CD4(+) T cells (mean +/- SD: 7.85 +/- 2.62% versus 11.68 +/- 3.78%, P < 0.005). Moreover, there were statistically significant inverse correlations between the levels of CD4(+)CD25(+bright) T cells and some parameters of inflammation or immune activation including erythrocyte sedimentation rate, C-reactive protein, IgG and rheumatoid factors. The result suggested that CD4(+)CD25(+bright) T cells were likely to play anti-inflammatory and immunosuppressive roles in the pathogenesis of pSS. However, the exact functions of decreased circulating CD4(+)CD25(+bright) T cells in pSS need further elucidated. Lupus (2008) 17, 34-39.
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