期刊
LUNG CANCER
卷 80, 期 1, 页码 85-90出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2012.12.018
关键词
Aurora-B; Aneuploidy; NSCLC; Aurora-A; Ki-67; Prognosis
资金
- Japanese Ministry of Education, Culture, Sports, Science, and Technology, Tokyo, Japan [16209012, 17590305, 1920912, 22590316]
- Grants-in-Aid for Scientific Research [17590305, 22590316, 16209012, 25460438] Funding Source: KAKEN
Aurora-B is a key regulator of mitosis, and the overexpression has been detected in a variety of solid tumors. The Aurora-B overexpression has been suggested to correlate with clinical aggressiveness and aneuploidy in vitro, however, the frequency of overexpression of Aurora-B protein, the association with clinicopathologic parameters and aneuploidy remain poorly defined in non-small-cell lung cancer (NSCLC). Using 157 surgical specimens of human NSCLC, we here show that overexpression of Aurora-B proteins are significantly correlated with aneuploidy and poor outcomes in NSCLC. We examined immunohistochemical protein expression of Aurora-B, and DNA ploidy by laser scanning cytometry in 157 NSCLC cases. Aurora-B overexpression was found in 83 cases (53%) of NSCLC, and was significantly correlated with vascular invasion (p = 0.012), poor differentiation (p < 0.001), larger tumor size (p = 0.010) and lymph node metastasis (p = 0.05) and poor prognosis (p = 0.011). Aneuploidy was found in 87 cases (57%), and was significantly correlated with Aurora-B overexpression (p = 0.0065). Logistic multivariate analysis revealed overexpression of Aurora-B protein to be significant risk factors for aneuploidy compared with other factors. These results indicate that Aurora-B overexpression may contribute to malignant potential and increased aneuploidy in NSCLC. Thus, Aurora-B may serve as a new therapeutic target in against patients with NSCLC, although further studies will be necessary. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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