期刊
LUNG CANCER
卷 80, 期 1, 页码 106-108出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2013.01.003
关键词
Thymic; Carcinoma; Sunitinib; c-Kit; GIST; Imatinib
Thymic carcinoma (TC) is a rare intrathoracic malignancy that it can be invasive and refractory to conventional treatment. Comprehensive genomic analysis evidenced a molecularly distinct subset of thymic carcinoma with high prevalence of c-kit mutation, which may behave as a gastrointestinal stromal tumor (GIST). Here, we present a case report of TC with c-Kit mutation, who has relapsed after exposure to multiple lines of combination chemotherapy, but he has shown an impressive and long lasting response to sunitinib after imatinib failure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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