期刊
LUNG CANCER
卷 70, 期 2, 页码 188-194出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2010.02.006
关键词
Dendritic cells; Electroporation; Immunotherapy; Non-small cell lung carcinoma; Tumor vaccines
资金
- Dong-A University
Background: A dendritic cell vaccine has been developed as a novel strategy for generating antitumor immunity in the treatment of cancer. The purpose of this study was to assess the maximal tolerated dose, safety, and immunologic response of a new dendritic cell vaccine (DC-Vac) into which tumor lysate was loaded by electroporation and pulse in patients with advanced non-small cell lung cancer (NSCLC). Patients and methods: Fifteen patients with inoperable stage III or IV NSCLC were assigned to cohorts that received 3, 6, or 12 x 10(6) DC-Vac intradermally 3 times at 2 week intervals. We also evaluated immunologic and tumor responses. Results: The maximum dose of DC-Vac (12 x 10(6)) was shown to be safe. In 5 of 9 patients, the vaccine resulted in increased interferon (IFN)-gamma production by CD8+ cells after exposure to tumor lysate. Additionally, there were mixed responses which do fulfill progressive disease definition but demonstrate some clinical benefit in two patients. Conclusion: The administration of tumor lysate-loaded autologous dendritic cells by electroporation and pulse was non-toxic and induced immunologic responses to tumor antigens. The two mixed tumor responses which were achieved may represent a potential benefit of this new DC-Vac. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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