期刊
LUNG CANCER
卷 64, 期 2, 页码 179-186出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.lungcan.2008.08.003
关键词
EGFR; FISH; EGFR gene copy number; CT; FDG-PET; Adenocarcinoma; Lung
资金
- Seoul National University Hospital Research Fund [04-2005-032]
- Sang Koo Hahn Research Fund
It has been suggested that a high EGFR gene copy number may be an indicator of good response to EGFR tyrosine kinase inhibitor therapy and a marker of poor prognosis in NSCLC. However, imaging features related to EGFR gene copy number status in adenocarcinoma are still unknown. We therefore retrospectively analyzed CT, FDG-PET, and histopathologic slides of surgical resected lung adenocarcinoma in 132 patients. Tumor characteristics on preoperative chest-CT, such as, GGO proportions, tumor diameters, and cavitation: FDG-PET SUVmax; and histopathologically determined differentiation degrees and tumor subtypes were evaluated. EGFR gene copy number status was categorized as FISH-positive or -negative. FISH-positivity was found in 53 patients (40.2%) and was significantly more frequent in tumors with a SUVmax > 7.0 (P = 0.007). Furthermore, FISH-negativity was found to be more frequent in tumors with a GGO > 50% (P = 0.023) and diameter <15.5 mm (P = 0.006) on CT, or a well-differentiated histopathology (P = 0.002). Moreover, the frequency of FISH-positivity increased as SUVmax increased (P = 0.0008) and as the proportion of GGO decreased (P = 0.01). SUVmax > 7.0 was an independent predictor of FISH-positive results (odds ratio, 3.941; 95% CI, 1.691-9.182; P = 0.01). In conclusion, a high SUVmax on FDG-PET was significantly related to FISH-positive results. A high proportion of GGO, small tumor diameter on CT, and a well-differentiated histopathology were more frequent in FISH-negative adenocarcinomas. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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