期刊
LUNG
卷 188, 期 3, 页码 259-262出版社
SPRINGER
DOI: 10.1007/s00408-009-9207-x
关键词
Spinal cord injury; Tetraplegia; Fraction exhaled nitric oxide; Nitric oxide; Asthma
资金
- Rehabilitation Research and Development (RR&D) Service Career Development award [B4335 V]
- RR&D Center of Excellence for the Medical Consequences of Spinal Cord Injury [B4162C]
- Department of Veterans Affairs Rehabilitation Research and Development
The role of airway inflammation in mediating airflow obstruction in persons with chronic traumatic tetraplegia is unknown. Measurement of the fraction of exhaled nitric oxide (FeNO) affords a validated noninvasive technique for gauging the airway inflammatory response in asthma, although it has never been assessed in persons with tetraplegia. This study was designed to determine the FeNO in individuals with chronic tetraplegia compared with that in patients with mild asthma and healthy able-bodied individuals. Nine subjects with chronic tetraplegia, seven subjects with mild asthma, and seven matched healthy able-bodied controls were included in this prospective, observational, pilot study. All subjects were nonsmokers and clinically stable at the time of study. Spirometry was performed on all participants at baseline. FENO was determined online by a commercially available closed circuit, chemiluminescence method, using a single-breath technique. Subjects with tetraplegia had significantly higher values of FeNO than controls (17.72 +/- A 3.9 ppb vs. 10.37 +/- A 4.9 ppb; P a parts per thousand currency sign 0.01), as did subjects with asthma (20.23 +/- A 4.64 ppb vs. 10.37 +/- A 4.9 ppb, P a parts per thousand currency sign 0.001). There was no significant difference in FeNO between subjects with tetraplegia and those with asthma (17.72 +/- A 3.9 ppb vs. 20.23 +/- A 4.64 ppb, P a parts per thousand currency sign 0.27). Individuals with chronic tetraplegia have FeNO levels that are comparable to that seen in mild asthmatics and higher than that in healthy able-bodied controls. The clinical relevance of this observation has yet to be determined.
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