期刊
LIVER INTERNATIONAL
卷 35, 期 3, 页码 1036-1047出版社
WILEY
DOI: 10.1111/liv.12574
关键词
advanced stage; primary liver cancer; sorafenib; transarterial radiotherapy; treatment
Background & AimsSorafenib and transarterial Y-90-radioembolization (TARE) are possible treatments for Barcelona Clinic Liver Cancer (BCLC) intermediate-advanced stage hepatocellular carcinoma (HCC). No study directly comparing sorafenib and TARE is currently available. This single-centre retrospective study compares the outcomes achieved with sorafenib and TARE in HCC patients potentially amenable to either therapy. MethodsSeventy-four sorafenib (7110years, male 87%, BCLC B/C 53%/47%) and 63 TARE HCC patients (669years, male 79%, BCLC B/C 41%/59%) were included based on the following criteria: Child-Pugh class A/B, performance status 1, HCC unfit for other effective therapies, no metastases and no previous systemic chemotherapy. ResultsMedian overall survivals of the two groups were comparable, being 14.4months (95% CI: 4.3-24.5) in sorafenib and 13.2months (95% CI: 6.1-20.2) in TARE patients, with 1-, 2- and 3-year survival rates of 52.1%, 29.3% and 14.7% vs 51.8%, 27.8% and 21.6% respectively. Two TARE patients underwent liver transplantation after successful down-staging. To minimize the impact of confounding factors on survival analysis, propensity model matched 32 patients of each group for median age, tumour gross pathology and the independent prognostic factors (portal vein thrombosis, performance status, Model for End Liver Disease). Even after matching, the median survival did not differ between sorafenib (13.1months; 95% CI: 1.2-25.9) and TARE patients (11.2months; 95% CI: 6.7-15.7), with comparable 1-, 2- and 3-year survival rates. ConclusionsIn cirrhotic patients with intermediate-advanced or not-otherwise-treatable HCC, sorafenib and TARE provide similar survivals. Down-staging allowing liver transplantation only occurred after TARE.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据