期刊
LIVER INTERNATIONAL
卷 34, 期 3, 页码 330-342出版社
WILEY
DOI: 10.1111/liv.12338
关键词
cell therapy; chemokines; hepatocellular carcinoma; mesenchymal stromal cells; migration
资金
- Austral University [T13-11]
- Agencia Nacional de Promocion Cientifica yTecnologica (ANPCyT) [PICT-2007/00082]
- PICTO [2008/00115, 2008/00122]
- PICT [2008/00123, 2010/2818]
Mesenchymal stromal cells (MSCs) are more often obtained from adult and extraembryonic tissues, with the latter sources being likely better from a therapeutic perspective. MSCs show tropism towards inflamed or tumourigenic sites. Mechanisms involved in MSC recruitment into tumours are comprehensively analysed, including chemoattractant signalling axes, endothelial adhesion and transmigration. In addition, signals derived from hepatocellular carcinoma (HCC) tumour microenvironment and their influence in MSC tropism and tumour recruitment are dissected, as well as the present controversy regarding their influence on tumour growth and/or metastasis. Finally, evidences available on the use of MSCs and other selected progenitor/stem cells as vehicles of antitumourigenic genes are discussed. A better knowledge of the mechanisms involved in progenitor/stem cell recruitment to HCC tumours is proposed in order to enhance their tumour targeting which may result in improvements in cell-based gene therapy strategies.
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