期刊
RADIOLOGY
卷 274, 期 1, 页码 250-259出版社
RADIOLOGICAL SOC NORTH AMERICA
DOI: 10.1148/radiol.14140080
关键词
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资金
- Severe Asthma Research Program, National Institutes of Health [U10 HL109257]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [U10HL109257] Funding Source: NIH RePORTER
Purpose: To quantify regional lung ventilation in healthy volunteers and patients with severe asthma (both before and after thermoplasty) by using a combination of helium 3 (3He) magnetic resonance (MR) imaging and computed tomography (CT), with the intention of developing more effective image-guided treatments for obstructive lung diseases. Materials and Methods: With approval of the local institutional review board, informed consent, and an Investigational New Drug Exemption, six healthy volunteers and 10 patients with severe asthma were imaged in compliance with HIPAA regulations by using both multidetector CT and 3He MR imaging. Individual bronchopulmonary segments were labeled voxel by voxel from the CT images and then registered to the 3He MR images by using custom software. The 3He signal intensity was then analyzed by evaluating the volumeweighted fraction of total-lung signal intensity present in each segment (segmental ventilation percentage [SVP]) and by identifying the whole-lung defect percentage and the segmental defect percentage. Of the 10 patients with asthma, seven received treatment with bronchial thermoplasty and were imaged with 3He MR a second time. Changes in segmental defect percentages and whole-lung defect percentages are presented. Results: Ventilation measures for healthy volunteers yielded smaller segment-to-segment variation (mean SVP, 100% 6 18 [ standard deviation]) than did the measures for patients with severe asthma (mean SVP, 97% 6 23). Patients with asthma also demonstrated larger segmental defect percentages (median, 13.5%; interquartile range, 8.9%-17.8%) than healthy volunteers (median, 6%; interquartile range, 5.6%-6.3%). These quantitative results confirm what is visually observed on the 3He images. A Spearman correlation of r = 20.82 was found between the change in whole-lung defect percentage and the number of days between final treatment and second 3He imaging. Conclusion: Regional quantification of lung ventilation is indeed feasible and may be a useful technique for image-guided treatment of obstructive lung diseases, such as bronchial thermoplasty for severe asthma. In these patients, ventilation defects decreased as a function of time after treatment. (C) RSNA, 2014
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