期刊
LIPIDS
卷 46, 期 9, 页码 805-811出版社
WILEY
DOI: 10.1007/s11745-011-3568-7
关键词
Ethanolic extract of propolis; Reverse cholesterol transport; High density lipoprotein; ATP-binding cassette transporters A1; ATP-binding cassette transporters G1; Scavenger receptor BI
资金
- Tai Shan Scholars foundation of Shandong province [ZD056, ZD057]
- special foundation of Tai Shan Medical College [1065]
The ethanolic extract of propolis (EEP) is beneficial in increasing high density lipoprotein (HDL) cholesterol (HDL-C) and diminishing risks of atherosclerosis. In this study, we examined the effects of EEP on reverse cholesterol transport in mice. H-3 -cholesterol laden macrophage was injected intraperitoneally into mice fed by gastric gavage with EEP. Plasma lipid level was determined and H-3-cholesterol was traced in plasma, liver and feces. The effects of EEP on ATP-binding cassette transporter A1 and G1 (ABCA1 and ABCG1) and scavenger receptor BI (SR-BI) in mice liver and in cultured cells were also investigated. EEP administration led to a significant increase in HDL-C and peritoneal macrophage-original H-3-cholesterol in plasma, liver and feces. Liver protein expressions of ABCA1 and ABCG1 were increased but SR-B1 was not. In vitro experiments with HepG2 and Raw264.7 cell lines confirmed the above results. The finding of these studies shows that EEP-enhanced reverse cholesterol transport may have resulted from EEP stimulated plasma HDL level and hepatic ABCA1 and ABCG1 expression.
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