期刊
LIFETIME DATA ANALYSIS
卷 15, 期 4, 页码 468-492出版社
SPRINGER
DOI: 10.1007/s10985-009-9134-4
关键词
Censoring; Clinical trials; Ethical design; Optimal design; Survival data; Two-stage designs
A randomized two-stage adaptive Bayesian design is proposed and studied for allocation and comparison in a phase III clinical trial with survival time as treatment response. Several exact and limiting properties of the design and the follow-up inference are studied, both numerically and theoretically, and are compared with a single-stage randomized procedure. The applicability of the proposed methodology is illustrated by using some real data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据