期刊
LIFE SCIENCES
卷 89, 期 5-6, 页码 171-175出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2011.05.012
关键词
STAT4; Rheumatoid arthritis; Single nucleotide polymorphisms; Case-control study
资金
- Ministry of Science and Technology of P. R. China [2006DKA21301]
- National Natural Science Foundation of China [30972708]
- National Science Foundation of China [81071701]
Aims: Signal transducer and activator of transcription 4 (STAT4) gene encode a transcriptional factor that transmits signals induced by several key cytokines which play important roles in the development of autoimmune diseases. Recently, several single nucleotide polymorphisms (SNPs) in STAT4 gene have been reported to be significantly associated with Rheumatoid arthritis (RA) in different ethnic populations. We undertook this study to investigate whether the association of STAT4 genetic polymorphisms with RA is present in Northwestern Chinese Han population. Main methods: A case-control association study in individuals with RA (n = 208) and healthy controls (n = 312) was conducted. Four SNPs (rs7574865, rs8179673, rs10181656, rs11889341) in STAT4 gene were genotyped by using polymerase chain reaction followed by denaturing high-performance liquid chromatography (PCR-DHPLC) and DNA sequencing. Key findings: The genotype and allele distributions of four polymorphisms were significantly different in individuals with RA compared to controls, with SNP rs7574865 T allele and T/T genotype showing the most significant association with susceptibility to RA (uncorrected P= 1 x 10(-4), OR= 1.645, 95% CI = 1.272-2.129; uncorrected P = 4.8 x 10(-5), OR = 3.111, 95% CI = 1.777-5.447, respectively). Stratification studies showed that STAT4 gene polymorphisms were significantly associated with anti-cyclic citrullinated peptide (anti-CCP) positive subgroup in Northwestern Chinese Han population. Significance: These findings strongly suggest that STAT4 genetic polymorphisms are associated with RA in Northwestern Chinese Han population, and support the hypothesis of STAT4 gene polymorphisms increasing the risk for RA across major populations. (C) 2011 Elsevier Inc. All rights reserved.
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