期刊
LIFE SCIENCES
卷 83, 期 9-10, 页码 305-312出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2008.06.024
关键词
signal transduction; transcription factor Sp1; O-linked beta-N-acetylglucasamine (O-GlcNAc); phosphorylation; calmodulin gene expression
资金
- Department of Veterans Affairs (DVA)
- National Institutes of Health
Specificity protein 1 (Sp1) belongs to a family of ubiquitously expressed, C2H2-type zinc finger-containing DNA binding proteins that activate or repress transcription of many genes in response to physiological and pathological stimuli. There is emerging evidence to indicate that in addition to functioning as 'housekeeping' transcription factors, members of Sp family may be key mediators of gene expression induced by insulin and other hormones. The founding member of the family, Sp1, by virtue of its multi-domain organization, potential for posttranslational modifications and interactions with numerous transcription factors, represents an ideal mediator of nuclear signaling in response to hormones. Insulin regulates the subcellular localization, stability and trans-activation potential of Sp1 by dynamically modulating its posttranslational modification by O-linked beta-N-acetylglucosamine (O-GlcNAc) or phosphate residues. We briefly review the recent literature demonstrating that an involvement of Sp-family of transcription factors in the regulation of differential gene expression in response to hormones is more common than previously appreciated and may represent a key regulatory mechanism. Published by Elsevier Inc.
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