期刊
LEUKEMIA RESEARCH
卷 38, 期 2, 页码 243-250出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.11.012
关键词
Stat3; cr-abl; Chronic myeloid leukemia; Imatinib
资金
- South Egypt Cancer Institute
Flowcytometry analysis was carried out to evaluate the expression of the p-Stat3 in 50 CML patients and 20 age-matched healthy controls. p-Stat3 expression was increased in advanced stages of CML. Imatinib treatment was found to suppress the expression of p-Stat3 in bone marrow cells. The level of p-Stat3 was found to be higher in resistant cases than in responsive cases, which suggest the beneficial use of p-Stat3 as an indicator to follow the clinical course and the treatment response. (C) 2013 Elsevier Ltd. All rights reserved.
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