期刊
LEUKEMIA RESEARCH
卷 38, 期 5, 页码 525-531出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2014.02.010
关键词
Multiple Myeloma; MM-related bone disease; Macrophage inflammatory protein-1 alpha; Sclerostin
资金
- Natural Science Foundation of Guangxi Province of China [2012GXNSFAA053112]
- Guangxi Natural Science Returning Foundation [2010gxnsfc013016]
- Science and Technology Development Foundation of Guilin City [20110119-1-12]
The aim of the study was to investigate the expression of MIP-1 alpha and sclerostin in bone marrow of patients with multiple myeloma (MM), the possible association of the sclerostin and MIP-1 alpha with MBD and the clinical characteristics. 53 patients (29 M, 24 F), median age 64 years was studied. MIP-1 alpha, sclerostin and bone-specific alkaline phosphatase (bALP) levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Sclerostin and MIP-1 alpha mRNA expression was determined by RT-PCR. PTH and 1,25(OH) 2D3 levels were measured with an electrochemiluminescence immunoassay. The sclerostin and MIP-1 alpha concentrations in patients with MM were higher than those in the controls. RT-PCR analysis verified that the bone marrow mononuclear cells (BMMNCs) of most patients showed sclerostin and MIP-1 alpha mRNA expression. The sclerostin and MIP-1 alpha levels in patients with ISS stage III disease were significantly higher than those in patients with ISS stage II disease (p = 0.01 and 0.06). The sclerostin and MIP-1 alpha levels in patients with BMD in group C were significantly higher than those in group A + B. There was positive correlation between sclerostin levels and MIP-1 alpha, beta2-microglobulin and aCa levels. A negative association was seen between sclerostin levels and bALP, HB and ALB levels. The MM patients with high sclerostin levels (> 0.72 ng/ml) had significantly shorter median survival than those with low sclerostin levels (<= 0.72 ng/ml) (chi(2) = 7.574, p = 0.006). Our findings support the positive relationship between sclerostin levels and MIP-1alpha levels deserve further detailed research. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据