期刊
LEUKEMIA RESEARCH
卷 38, 期 10, 页码 1184-1190出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2014.06.018
关键词
Leukemia; Polypharmacy; Medications; Elderly; Older; Mortality
资金
- Doug Coley Foundation
- American Society of Hematology
- Atlantic Philanthropies
- John A. Hartford Foundation
- Association of Specialty Professors
- Paul Beeson Career Development Award in Aging Research [K23AG038361]
- NIA
- AFAR
- Gabrielle's Angel Foundation for Cancer Research
We retrospectively evaluated the prognostic significance of polypharmacy and inappropriate medication use among 150 patients >60 years of age receiving induction chemotherapy for acute myelogenous leukemia (AML). After adjustment for age and comorbidity, increased number of medications at diagnosis (>= 4 versus <= 1) was associated with increased 30-day mortality (OR=9.98, 95% CI=1.18-84.13), lower odds of complete remission status (OR=0.20, 95% CI=0.06-0.65), and higher overall mortality (HR=2.13, 95% CI=1.15-3.92). Inappropriate medication use (classified according to Beers criteria) was not significantly associated with clinical outcomes. Polypharmacy warrants further study as a modifiable marker of vulnerability among older adults with AML. (C) 2014 Elsevier Ltd. All rights reserved.
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