期刊
LEUKEMIA RESEARCH
卷 38, 期 2, 页码 225-235出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.11.007
关键词
GPR37; CAM DR; PI3K/Akt; MAPK/ERK; Proliferation
资金
- National Natural Science Foundation of China [81172879, 81201858]
- Natural Science Foundation of Jiangsu province [BK2012231]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The orphan G protein-coupled receptor 37 (GPR37) is homologous to endothelin (ETB-R) and bombesin (GRP-R, NMB-R) receptors. The present study was undertaken to determine the expression and functional significance of GPR37 in human multiple myeloma (MM). We found that GPR37 was lowly expressed in MM cell adhesion model and highly expressed in proliferating cells. In vitro, meddling with the expression of GPR37 affected the CAM-DR by regulating the ability of cell adhesion and the activity of Akt and ERK in MM cells. Further studies indicated the positive role of GPR37 in the proliferation of MM cells. (C) 2013 Elsevier Ltd. All rights reserved.
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