期刊
LEUKEMIA RESEARCH
卷 37, 期 3, 页码 274-279出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.11.013
关键词
Acute myeloid leukemia; Cytokines; Chemokines; Interleukins; Tumor necrosis factor; Interferon; Cancer-related fatigue; Quality of life
资金
- Canadian Institutes of Health Research [MOP 86697]
Cancer-related fatigue (CRF) is a major problem in patients with acute myeloid leukemia (AML) and may be mediated by circulating cytokines. We examined this relationship in 74 adult AML patients before and after the first cycle of induction chemotherapy. Plasma levels of 13 cytokines were measured via electrochemiluminescence. At baseline, potentially clinically important (r > 0.30) correlations were seen between tumor necrosis factor (TNF)-alpha and fatigue (r = -0.336, p = 0.017). Over time, correlations with fatigue were noted with TNF-alpha (r = -0.341, p = 0.006) and interferon-inducible protein (IP)-10 (r = 0.353, p = 0.005). The link between IP-10 and fatigue is novel, implicating CXC chemokine pathways for CRF in hematologic malignancies. (C) 2012 Elsevier Ltd. All rights reserved.
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