期刊
LEUKEMIA RESEARCH
卷 37, 期 10, 页码 1213-1215出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.07.038
关键词
Follicular lymphoma; Immunology; Lymphocyte subsets; NK cells; Prognosis
资金
- NCI [P30 CA006927]
- Janice Charach Epstein Lymphoma Research Fund
Host immune responses influence follicular lymphoma (FL) outcomes. To test our hypothesis that immune cells in blood reflect that response, we assessed by peripheral blood flow cytometry in 75 untreated FL patients the absolute counts of: lymphocytes (ALC), CD4(+)T (ACD4C), CD8(+)T (ACD8C) and natural killer (ANKC) cells. Low ANKC was the only parameter associated with inferior overall survival by univariate analysis (p = 0.02), and trended to significance in multivariable analysis with ACD4C (p = 0.08). Five (24%) patients with low initial ANKC died, while one (2%) with normal/high ANKC has died. In conclusion, evaluation of blood ANKC may be a useful indicator of outcome in previously untreated FL patients. (C) 2013 Elsevier Ltd. All rights reserved.
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