期刊
LEUKEMIA RESEARCH
卷 37, 期 9, 页码 1021-1026出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2013.05.002
关键词
Acute myeloid leukemia with t(8;21); CD56 antigen; Prognostic factor
资金
- Ministry of Health, Labor, and Welfare of Japan
- Grants-in-Aid for Scientific Research [24591407, 24659324] Funding Source: KAKEN
We investigated the significance of surface antigen expression for prognosis by focusing on a specific subtype, AML with t(8;21). The investigation included 144 patients with AML with t(8; 21) in the JALSG AML97 study. AML with t(8; 21) expressed CD19 (36%), CD34 (96%), and CD56 (65%) more frequently than did other subtypes of AML. CD19 expression had a significant favorable effect on CR (95.7% vs. 83.8%; P = 0.049). Univariate analysis showed that increased white blood cell (WBC) counts (WBC >= 20 x 10(9)/L), CD19 negativity, and CD56 positivity were critical adverse factors for relapse after CR; multivariate analysis revealed that WBC count and CD56 expression were independent adverse risk factors (HR 2.18; P = 0.045, HR 2.30; P = 0.011, respectively). We concluded that CD56 expression has a possible role in risk stratification for patients with AML with t(8; 21). (C) 2013 Elsevier Ltd. All rights reserved.
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