4.4 Article

56Fe Irradiation Alters Spine Density and Dendritic Complexity in the Mouse Hippocampus

期刊

RADIATION RESEARCH
卷 184, 期 6, 页码 586-594

出版社

RADIATION RESEARCH SOC
DOI: 10.1667/RR14103.1

关键词

-

资金

  1. NASA [NNX08BA07G, NNX13AD60G]
  2. NASA [NNX08BA07G, 91690, NNX13AD60G, 474979] Funding Source: Federal RePORTER

向作者/读者索取更多资源

A unique feature of the space radiation environment is the presence of high-energy charged particles, which can be significantly hazardous to space flight crews who are exposed during a mission. Health risks associated with high-LET radiation exposure include cognitive injury. The pathogenesis of this injury is unknown but may involve modifications to dendritic structure and/or alterations in dendritic spine density and morphology. In this study, 24 two-month-old C57BL6/J male mice were either whole-body irradiated with 0.5 Gy 56Fe (600 MeV/n; n = 12) or sham irradiated (n = 12). Three months postirradiation animals were tested for locomotor activity and habituation. After behavioral testing, animals were euthanized and the brains were flash frozen. Compared to sham-irradiated mice, irradiated mice moved less when first introduced to the environment, although they did recognize the environment when re-exposed to it one day later. Exposure to 56Fe radiation significantly compromised the dendritic architecture and reduced spine density throughout the hippocampal tri-synaptic network. To our knowledge, these data represents the first reported evidence that high-LET radiation has deleterious effects on mature neurons associated with hippocampal learning and memory. (C) 2015 by Radiation Research Society

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据