期刊
LEUKEMIA RESEARCH
卷 36, 期 7, 页码 846-851出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.03.017
关键词
CD105; Placental growth factor; Acute lymphoblastic leukaemia; Prognosis
资金
- Ministry of Sciences and Higher Education [0059/B/P01/2008/35]
The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytochemical assays respectively. Kaplan-Meier statistics revealed CD105 and PlGF expression as managed separately do not correlate with relapse-free time in ALL patients. On the other hand, an associated analysis of CD105 and PlGF demonstrated a significantly shorter progression-free time in children who were CD105+ and PlGF+ or CD105- and PlGF+ at the moment of ALL diagnosis. (C) 2012 Elsevier Ltd. All rights reserved.
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