期刊
LEUKEMIA RESEARCH
卷 36, 期 9, 页码 1082-1088出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2012.06.001
关键词
Leukemia; Model; Transgenic; Xenotransplantation; Zebrafish
资金
- Foundation for Paediatric Research in Finland
- Finnish Medical Foundation
- Nona and Kullervo Vare Foundation
- Competitive Research Funding of Tampere University Hospital [9L070, 9K073, 9M052, 9M093]
- Academy of Finland Research Council for Health [135736, 139225]
- Biocenter Finland
- Tampere Tuberculosis Foundation
- Emil Aaltonen Foundation
- Academy of Finland (AKA) [135736, 139225, 135736, 139225] Funding Source: Academy of Finland (AKA)
The zebrafish has proven to be a valuable vertebrate model in which to elucidate the molecular mechanisms of various diseases. A high degree of genetic and morphological similarity in hematopoiesis between the zebrafish and human indicates that zebrafish can provide valuable knowledge about the mechanisms behind pathogenesis of leukemia. To date, a small number of zebrafish leukemia models have been published and they have already provided some interesting information. However, the full potential of these models, especially the identification of contributing genetic factors and high-throughput drug screens, is yet to be fulfilled. Further transgenic or mutant animals are needed, especially for modeling high-risk leukemias, such as MLL rearranged infant leukemias. (c) 2012 Elsevier Ltd. All rights reserved.
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