期刊
LEUKEMIA RESEARCH
卷 35, 期 6, 页码 771-776出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2010.11.023
关键词
Acute myeloid leukemia; Chronic myeloid leukemia; CMTM5; Methylation; Tumor suppressor gene
资金
- Peking University People's Hospital Research and Development Foundation [RDC2009-39]
- National Natural Science Foundation of China [30670894]
- National High Technology Research and Development Program of China (863 Program) [2006AA02A405, 2006AA02A305]
CMTM5 has been shown to exhibit tumor suppressor activities, however, its role in leukemia is unclear. Herein we firstly reported the expression and function of CMTM5 in myeloid leukemia. CMTM5 was down-regulated, or undetectable, in leukemia cell lines and bone marrow cells from leukemia patients with promoter methylation. Ectopic expression of CMTM5-v1 strongly inhibited the proliferation of K562 and MEG-01 cells. In addition, significant negative correlations were observed between CMTM5 and three leukemia-specific fusion genes (AML1-ETO, PML-RAR alpha and BCR/ABL1). CMTM5 expression was up-regulated in patients who had undergone treatment. Therefore, CMTM5 may be involved in the pathomechanism of myeloid leukemias. (C) 2010 Elsevier Ltd. All rights reserved.
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