期刊
LEUKEMIA RESEARCH
卷 35, 期 8, 页码 1102-1107出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2011.03.027
关键词
Myelodysplastic syndromes; Bone marrow microenvironment; Thalidomide; Cytokines; Interleukin-10
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- Fundacao de Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
The purpose of this study was to investigate the in vitro effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndrome. We demonstrated that thalidomide induced an increase in granulocyte-macrophage colony forming unit numbers and in IL-10 expression. Thalidomide also promoted a slight increase in IL-6, IL-1 beta and TNF-alpha expression in the stromal layers. The numbers of erythroid burst forming units, the apoptosis rate of hematopoietic cells, and VEGF and TNF-alpha expression levels in culture supernatants were not modulated. Our results indicate a participation of thalidomide upon the hematopoietic microenvironment of patients with myelodysplastic syndromes, especially in the up regulation of IL-10. (C) 2011 Elsevier Ltd. All rights reserved.
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