期刊
LEUKEMIA RESEARCH
卷 34, 期 3, 页码 294-300出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.08.024
关键词
Febrile neutropenia; Prognosis; Hematologic malignancy; Albumin; Bicarbonate; C-reactive protein
We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model. (C) 2009 Published by Elsevier Ltd.
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