期刊
LEUKEMIA RESEARCH
卷 34, 期 3, 页码 284-288出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.07.008
关键词
Chronic lymphocytic leukemia (CLL); Chemoimmunotherapy; Mitoxantroe; Nucleoside analogs
资金
- OSI Pharmaceuticals
Randomized trials demonstrated the superiority of chemoimmunotherapy over chemotherapy in the frontline treatment of CLL. Based on favorable experience with the addition of mitoxantrone (M) to fludarabine (F) plus cyclophosphamide (C), we designed a pilot study testing the combination of FCM plus rituximab (R). Thirty patients with previously untreated, symptomatic CLL, <70 years, and beta-2-microglobulin
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