期刊
LEUKEMIA RESEARCH
卷 33, 期 10, 页码 1379-1385出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.03.028
关键词
Stem cells; Gene amplification; Multidrug resistance; ABCB1; ABCB4; ABCB5; SEMA3D
资金
- Norwegian Cancer Society and the Norwegian Research Council
- Microarray Facility of the Norwegian Microarray Consortium
- FUGE program
The transmembrane transporter P-glycoprotein (P-gp) encoded by ABCB1, is one major cause for multidrug resistance (MDR). We compared the genomic profile and gene expression pattern of the P-gp positive K562(VCR) cells with parental P-gp negative K562(wt) cells. In K562VCR array CGH revealed amplification of ABCB1, ABCB4, ABCB5 and SEMA3D, whereas expression microarrays demonstrated upregulation of stem cell genes (e.g. KIT and HOXB4), anti-apoptotic genes (e.g. IGF1R and CCNG1), and downregulation of proapoptotic genes (e.g. CASP4, 6 and 7). Thus, K562VCR cells disclose stem cell characteristics including a range of drug resistance mechanisms possibly attained as a stem cell program switched on en bloc. (c) 2009 Elsevier Ltd. All rights reserved.
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