期刊
LEUKEMIA RESEARCH
卷 33, 期 2, 页码 315-320出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2008.08.001
关键词
Transferrin; Apo-transferrin; Interleukin-18 (IL-18); Proliferation; Leukemia
资金
- Korea Science & Engineering Foundation (KOSEF) through the Research Center for Women's Disease (RCWD) at Sookmyung Women's University
- Korea Health 21 RD Project, Ministry of Health & Welfare, Republic of Korea [A050569]
- Seoul Research and Business Development Program [10582]
- Korea Health Promotion Institute [A050569] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Transferrin is an iron carrier protein involved in iron uptake and the regulation of cell growth. Although highly proliferative cells express transferrin and its receptor. little is known about the role of transferrin in the cellular response to cytokine production. The non-iron-bound form of transferrin (apo-transferrin) was administered to human chronic myeloid leukemia cell line, K-562 cells to assess Whether it could induce interleukin-18 (IL-18). Apo-transferrin enhanced IL-18 mRNA and protein and. moreover, IL-18 secretion was increased by treatment with apo-transferrin. In conclusion, apo-transferrin regulates IL-18 expression and we suggest that it is involved in cytokine production. (C) 2008 Elsevier Ltd. All rights reserved.
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