期刊
LEUKEMIA RESEARCH
卷 32, 期 6, 页码 904-912出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2007.08.010
关键词
angiopoietin; vascular endothelial growth factor; acute myeloid leukemia; survival
Angiogenic factors play an essential role in normal and pathologic angiogenesis, but their clinical role in acute myeloid leukemia (AML) remains unclear. We investigated the expression of Ang-1, Ang-2, Tie2, VEGF-A, and VEGF-C genes in bone marrow (BM) mononuclear cells by real-time quantitative PCR (RQ-PCR) in a cohort of 126 patients with newly diagnosed de novo AML and normal marrow donors. Here we show that high pre-treatment levels of Ang-2 in the BM indicate an unfavorable prognosis in AML. Only karyotype (hazard ratio 2.19, 95% CI 1.25-3.42, P = 0.005) and expression of Ang-2 (hazard ratio 2.05, 95% CI 1.20-3.52, P = 0.009), but not other angiogenic factors, were independent prognostic factors for overall survival by multivariate analysis. The prognostic significance of Ang-2 expression was more obvious in the subgroup of patients with intermediate-risk cytogenetics. Subgroup analysis showed that Ang-2 expression had prognostic impact on patients with low (but not high) Ang-1or Tie2 levels, and on patients with high (but not low) VEGF-A or VEGF-C levels. (c) 2007 Elsevier Ltd. All rights reserved.
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