期刊
LEUKEMIA & LYMPHOMA
卷 55, 期 12, 页码 2830-2834出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428194.2014.904508
关键词
Imatinib; copy drug; chronic myeloid leukemia; Glivec/Gleevec; complete hematologic response; Imatib
资金
- Novartis Pharmaceuticals Corporation
Imatinib (Glivec (R)/Gleevec (R)) has shown long-term efficacy and safety in randomized trials. No large-scale studies have prospectively assessed the benefit-risk profile of an imatinib copy drug. We prospectively evaluated the response of patients with chronic myeloid leukemia in chronic phase in one institution. Patients with a complete hematologic response (n = 126) switched from branded imatinib to an imatinib copy drug. Subsequently, all patients switched back to the branded imatinib. Many patients in this study had a loss of hematologic response and tolerability issues with the imatinib copy drug. Hematologic response and tolerability improved upon retreatment with branded Glivec.
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